Saypha® Hyaluronic Acid Facial Fillers

Hyaluronic acid is a natural element in our body and performs important functions such as maintaining moisture, firmness and elasticity of the skin. Environmental factors such as excessive sun exposure, smoking, poor diet, stress and the natural aging process affect the depletion of hyaluronic acid levels in our body.

As we age, hyaluronic acid levels decrease, which worsens the condition of our skin. It becomes drier, thinner and loses its flexibility and elasticity. Fine lines and wrinkles appear, the volume decreases and the overall harmony of the face is disturbed. Areas particularly affected by volume loss are the cheeks, lips, temples and lower jaw.

What are Saypha® dermal fillers?

Saypha® hyaluronic facial fillers belong to the Austrian pharmaceutical company Croma Pharma and are among the most widespread and recognizable anti-aging products.

The products are manufactured utilizing their innovative SMART (Supreme Monophasic and Reticulated Technology) system. . This manufacturing process increases the lifespan of the dermal filler when injected under the skin by optimizing the crosslinking and interlocking of the hyaluronic acid molecular chains.

Saypha® dermal fillers are transparent, sterile, biodegradable, high elasticity, isotonic, homogenized and monophasic. They use cross-linked and non-cross-linked hyaluronic acid (HA), of non-animal origin, created by biofermentation.

They have the ability to fill and smooth wrinkles, as well as create or restore volume, offering a overall rejuvenated appearance. Saypha® fillers are only injected by qualified doctors and their benefits include:

  • Correction of wrinkles and fine lines
  • Volume loss recovery
  • Lip volume correction and contour improvement
  • Improving skin tone and elasticity
  • Moisturizing and improving the overall appearance

The treatment is non-invasive, requires minimal recovery time and provides immediate, natural results. In addition, the procedure is mostly painless thanks to the combination of hyaluronic acid and lidocaine (local anesthetic). The results are visible immediately after the treatment and can last several months, depending on the specific product and its quantity.

Saypha filler portfolio

Saypha® portfolio

Saypha Filler

Saypha Filler is Croma’s softest product. The product comes in a 1 ml package and contains hyaluronic acid with a concentration of 23 mg/ml and the lowest degree of cross-linking compared to the other fillers in the portfolio. It is a single-phase hyaluronic acid gel that has many uses, including the treatment of moderate to severe wrinkles, lip contouring and volume, and lines and wrinkles around the mouth. It is injected into the mid to deep dermis with a 27½G needle and can be used on all areas of the face except around the eyes. The results are natural and long lasting. Available with or without added lidocaine for greater comfort during treatment. The degradation of the product takes place between 6 and 12 months.

Saypha Volume

It contains hyaluronic acid with a concentration of 23 mg/ml and is in the middle in terms of the degree of interconnection in relation to the other fillers in the portfolio. It is a viscoelastic, monophasic gel with hyaluronic acid, used to correct deep wrinkles, folds and scars, for facial contouring and volume reconstruction. It is injected into the deep dermis or bone with a 27G needle. It is produced in two versions – without and with lidocaine, which makes the procedures painless. The degradation of the product takes between 12 and 16 months.

Saypha Volume Plus

This is the densest filler from the Croma Pharma portfolio. It contains hyaluronic acid with a concentration of 25 mg/ml, with the highest degree of cross-linking compared to the rest of the group’s fillers. It is injected into the bone. It is used to restore volume in the middle and lower third of the face. Produced only with the addition of lidocaine.

Saypha Rich

A hyaluronic acid product used for deep hydration as it is injected into the superficial dermis with a 30G needle. It has a high concentration (18 mg/ml) of uncrosslinked hyaluronic acid, with a high molecular weight (3.0 million Daltons) and includes glycerol to improve skin hydration. It is used to improve the quality of the skin, reduce visible signs of aging and restore the skin’s radiance, contributing to an overall long-lasting rejuvenated look. It can also be used on the neck, décolleté and hands. The recommended treatment protocol is 3 sessions performed 3 weeks apart along with future maintenance. Degradation of the product takes between 12 and 18 months, depending on the amount, site of injection and other factors.

Can hyaluronic fillers be contraindicated in some people?

There are people who are not suitable for treatment with hyaluronic fillers. If the patient meets any of the following criteria, they are unfortunately not suitable for the procedure:

  • Be under the age of 18.
  • Women who are pregnant or breastfeeding.< /li>
  • Have a history of autoimmune disease or are currently receiving immunotherapy.
  • People who are prone to developing hypertrophic scars.
  • People who are hypersensitive to hyaluronic acid.
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  • The area they want to treat is currently injured, inflamed or infected.


First of all the patient must be completely healthy, without cold or flu. It is good to avoid taking painkillers and blood thinners, vitamins and nutritional supplements 7 days before the procedure. Alcohol consumption should be stopped 24-48 hours before. On the day of the procedure, it is desirable to reduce the consumption of caffeinated beverages and avoid heat (solarium, steam bath, laser and light treatments).
First your doctor will do a thorough examination to determine the appropriate treatment plan. Then the area to be treated is treated with a local anesthetic 10-15 minutes before the procedure. After the area is anesthetized, the product is injected into the dermis through a series of punctures. The duration of the process depends on the area being worked on. The average time is about 20 to 45 minutes.
Avoid makeup for at least a few hours after the procedure. Depending on the type of filler used and the area treated, massage at home for several days may be recommended. It is desirable not to be exposed to heat 1-2 weeks after the procedure (solarium, spa, steam rooms, saunas, etc.). It is good to avoid physical activity for a few days after the placement of the filler. When using hyaluronic filler, it is desirable to drink more water.
The local anesthetic and lidocaine contained in most products make the procedure painless. What you may feel is a very slight sting.
After the procedure, the skin in the treated area is swollen. Bruising can sometimes occur at the piercing sites, which disappear in a few days and can be covered with make-up in the meantime.
Hyaluronidase can be injected into the area to dissolve the filler.
Saypha is biodegradable, which means that the effect is not permanent due to the natural degradation of hyaluronic acid. Results can last several months, up to a year, depending on the Saypha product used, the area treated, and the individual's metabolism of the implanted HA. Saypha Filler is expected to last between 6 and 12 months, Volume between 12 and 16 months, Volume Plus between 12 and 18 months. After the mentioned interval, you can decide again if you want further treatment.

Before & After